A Conjugate of an Anti‐Epidermal Growth Factor Receptor (EGFR) VHH and a Cell‐Penetrating Peptide Drives Receptor Internalization and Blocks EGFR Activation

作者：Sanne A M van Lith; Dr Dirk van den Brand; Dr Rike Wallbrecher; Dr Sander M J van Duijnhoven; Dr Roland Brock; Dr William P J Leenders

来源：ChemBioChem, 2017, 18(24): 2390-2394.

DOI：10.1002/cbic.201700444

• antibodies
• cancer
• peptides
• receptors
• transpeptidation

Abstract(#br)Overexpression of (mutated) receptor tyrosine kinases is a characteristic of many aggressive tumors, and induction of receptor uptake has long been recognized as a therapeutic modality. A conjugate of a synthetically produced cell‐penetrating peptide (CPP), corresponding to amino acids ...

• 单位
  Radboud University