科研之友
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摘要
objective: to investigate the functional protection of heme-oxygenase-1 enzyme (ho-1) when using its inducer (hemin) and inhibitor (zinc protoporphyrin-znpp) in ischemic and toxic acute kidney injury by polymixin b in mice. materials: adult male wistar mice divided into 8 groups were used: sham (control), ischemic (isq), isq hemin (inducer of h0-1), isq znpp (inhibitor of h0-1), salina (control), polimyxin b (pmxb), pmxb hemin, pmxb znpp. method: analysis consists of jaff谷 (creatinine clearance [crcl]) and fox-2 (urinary peroxides [up]). results: thirty minutes renal ischemia and its treatment with pmxb reduced the crcl and maintained urinary output. urinary peroxide levels increased in both injuries. the administration of the inducer of h0-1 resulted in improvement in renal function and reduction in the levels of urinary peroxide. conclusions: findings indicated that ischemia and pmxb induce lar (acute kidney injury [aki]) by elevating the levels of urinary peroxide. the ho-1 inducer ameliorated the injury in both animal models through redox mechanism.
