Vulvovaginal candidiasis: An old disease with new challenges

作者：Soledad Miro Maria; Rodriguez Emilse; Vigezzia Cecilia; Alejandra Icely Paula; de Freitas Araujo Marcelo Gonzaga; Oscar Riera Fernando; Vargas Lara; Abiega Claudio; Pablo Caeiro Juan; Elena Sotomayor Claudia

来源：Revista Iberoamericana de Micologia, 2017, 34(2): 65-71.

DOI：10.1016/j.riam.2016.11.006

• Vulvovaginal candidiasis
• Candida spp.
• Virulence factors
• Innate receptors
• Vaginal epithelial cells
• Innate immune cells
• Treatment

Vulvovaginal candidiasis is an old disease that, even in a modern world, continues to have a high incidence. Despite the therapeutic advances, treatments are not always effective, and our understanding of the pathogenesis of this fungal, infection is still incomplete. A discussion is presented in this article on the Most significant developments related to the fungal virulence factors, the role of the immunological mechanisms involved in the vaginal protection, and the genetic alterations that confer susceptibility to the recurrent form of this mycosis. Current treatments, the use of new agents with antifungal activity, as well as the development of strategies, such as vaccination, are approached in the context of the complex scenario that governs the interactions between Candida and its host.