低共熔溶剂结合球磨工艺制备 MCC 及其在片剂中的应用性能研究

作者：Chen Tong; Li Jun; Xu Jun^*; Zhang Zhaohui; Ying Guangdong; Zhang Wei

来源：China Pulp and Paper, 2023, 42(5): 126-133.

DOI：10.11980/j.issn.0254-508X.2023.05.014

• deep eutectic solvents
• disintegration performance
• microcrystalline cellulose
• tablets

Three deep eutectic solvents（DES）of choline chloride/formic acid（ChCl/FA），choline chloride/oxalic acid（ChCl/OA），and choline chloride/citric acid（ChCl/CA）were used to treat poplar wood dissolving pulp，combined with ball milling process to prepare microcrystalline cellulose（MCC）. The effects of time and temperature on the properties of MCC polymerization and particle size under different DES systems were investigated. Using ibuprofen as a model drug，MCC was filled as a pharmaceutical excipient to investigate the effects of particle size and dosage of MCC on the properties of tablets such as disintegration time and dissolution degree. The results showed that the MCC prepared by ChCl/FA system at 100 ℃ for 60 min had the best mobility. Without adding disintegrant，when the filling amount of MCC was 35%，the disintegration time and the dissolution degree of tablets within 60 min could reach 190 s and 86. 58%，respectively，with high hardness and tensile strength. It showed that MCC prepared via DES method had a better filling effect as a pharmaceutical excipient. ? 2023 China Technical Association of Paper Industry.

• 单位
  华南理工大学