科研之友
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摘要
we report a case of bullous systemic lupus erythematosus in a 9-year-old female, with a vesiculobullous eruption on the trunk, neck, genitals and limbs. a skin biopsy specimen showed subepidermal blister with neutrophils. direct immunofluorescence revealed deposition of iga, igg, igm and c3 at the epithelial basement membrane zone and indirect immunofluorescence was negative. antinuclear antibodies and anti-sm were positive. resolution of the blisters occurred following treatment with dapsone and prednisone. this is a rare case of systemic lupus erythematous (sle) in the childhood, whose initial manifestation was a bullous eruption. bullous sle should be considered in the differential diagnosis of children presenting with generalized bullous eruption.
