Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder(复方青黄散)in Patients with Myelodysplastic Syndromes

作者：ZHAO Pan; LIANG Jun-bin; DENG Zhong-yang; WANG Ming-jing; QIN Jia-yue; CHEN Chong-jian; HU Xiao-mei

来源：Chinese Journal of Integrative Medicine, 2019, 25(06): 409-415.

Objective: To investigate the relationship between gene mutations and response to Compound Qinghuang Powder(复方青黄散, CQHP) in patients with myelodysplastic syndrome(MDS). Methods: Forty-three MDS patients after treatment with CQHP for 6 months were genotyped by ultra-deep targeted sequencing and the clinical data of patients were collected and the relationship between them was analyzed. Results: Up to 41.86%of patients harbored genet mutations, in most cases with more than one mutation. The most common mutations were in SF3B1, U2AF1, ASXL1, and DNMT3A. After treatment with CQHP, about 88.00% of patients no longer required blood transfusion, or needed half of prior transfusions. Conlusion: CQHP is an effective treatment for patients with MDS, especially those with gene mutations in SF3B1, DNMT3A, U2AF1, and/or ASXL1.

• 单位
  中医学科学院