科研之友
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摘要
objective: to assess different perinatal findings and sample collection timing in newborns with early-onset sepsis comparing those with low il-6 levels to the ones with high levels. methods: eighty-five newborn infants, with clinical signs of sepsis and/or positive blood cultures, had plasma il-6 collected in the initial evaluation for early-onset sepsis in the first 96 hours of life. they were classified in two groups according to their plasma il-6 levels: higher, and equal to or lower than il-6 median value for the whole septic group results: median il-6 for the whole group was 89 pg/ml. high and low level groups were formed by 42 and 43 newborns respectively. there were no differences between the two groups regarding gestational ages, birth weights, cesarean-section proportion, apgar scores, number of neonates with maternal risk factors for infection, number of maternal intrapartum antibiotic therapy, and number of positive blood cultures. median plasma il-6 in the high level group was 287 pg/ml, and in the low level group 46 pg/ml (p %26lt; 0.001). median sample timing was 17.5 hours of life for the high level group and 36 hours of life for the low level group (p %26lt; 0.001). there was a significant negative correlation coefficient between il-6 levels and sample collection timing. conclusion: sample collection timing is an important factor for detection of high plasma il-6 level in newborn infants with early-onset sepsis.
