Novel synthesis of tetrahydro-1H-pyrrolo[1,2-a]imidazol-2-ones via decarboxylative cyclization reaction of α-amino acids and α-ketoamides

作者：Wu, Jia-shou^*; Jiang, Hua-jiang; Yang, Jian-guo; Jin, Zheng-neng; Chen, Ding-ben

来源：Tetrahedron Letters, 2017, 58(6): 546-551.

DOI：10.1016/j.tetlet.2016.12.079

• alpha-Ketoamide
• alpha-Amino acid
• Azomethine ylide
• Decarboxylative cyclization
• Tetrahydro-1H-pyrrolo[1,2-a]imidazol-2-ones

An efficient and practical method was developed for the synthesis of tetrahydro-1H-pyrrolo[1,2-a]imidazol-2-ones based on the decarboxylative cyclization reaction of alpha-ketoamides and proline. In most cases,tetrahydro-1H-pyrrolo[1,2-a]imidazol-2-ones were obtained with perfect diastereoselectivity to give trans-isomer in excellent yield.

• 单位
  台州学院