Large scale in vivo micro‐RNA loss of function screen identified miR‐29a, miR‐100 and miR‐155 as modulators of radioresistance and tumor‐stroma communication

作者：Azadeh Fahim Golestaneh; Laura S M Lecker; Julian Schlegel; Ali Nowrouzi; Christian Schwager; Sarah Meister; Wilko Weichert; Jürgen Debus; Amir Abdollahi

来源：International Journal of Cancer, 2019, 144(11): 2774-2781.

DOI：10.1002/ijc.32019

• Micro RNA
• Radioresistance
• Functional genomics
• DNA damage response
• Angiogenesis

Micro RNAs (miR) are master regulators of cellular transcriptome. We aimed to investigate the role of miR regulation on tumor radiosensitivity and development of local tumor recurrence by a novel large‐scale in vivo loss of function screen. For stable miR silencing, human A431 tumor cells were trans...

• 单位
  German Cancer Research Center (DKFZ)