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摘要
Objective To study chemical constituents of total glycosides of Tufuling (Smilax glabra Roxb.). Methods The separation and purification of the chemical components of total glucosides of S. glabra was carried out systematically by silica gel column chromatography, gel chromatography and semi-preparative HPLC. The structures were identified by MS, NMR and CD spectral data in combination with the physicochemical properties of the isolated monomeric compounds. Results Twenty-five compounds were isolated from the total glucosides of S. glabra and identified as glabachromone A (1), sawarachromone (2), taxifolin (3), eriodictyol (4), naringenin (5), 3′,5′,5,7-tetrahydroxylflavanone (6), homoeriodictyol (7), 6-methoxynaringenin (8), dihydrokaempferol (9), 6-methoxyhesperetin (10), astilbin (11), isoastilbin (12), neoastilbin (13), neoisoastilbin (14), engeletin (15), isoengeletin (16), quercetin (17), luteolin (18), hispdulin (19), kaempferol (20), smiglanin (21), 5,7-dihydroxychromone (22), (＋)-catechin (23), (?)-epicatechin (24), and cinchonain Ib (25). Conclusion Compounds 1 is a new compound, compounds 2 and 8 are firstly isolated from the genus Smilax, and compound 6, 7, 8, 9, 19 and 22 are obtained from this plant for the first time. ? 2022 Editorial Office of Chinese Traditional and Herbal Drugs.
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