N-(4,4'-二氟苯甲基)哌嗪的合成

作者：唐龙骞; 孟昭力; 赵彦伟

来源：中国医药工业杂志, 2004, (06): 11.

• N-(4
• 4'-difluorobenzhydryl)piperazine
• lomerizine hydrochloride
• intermediate
• synthesis N-(4
• synthesis

N-(4,4'-Difluorobenzhydryl)piperazine, a key intermediate of lomerizine hydrochloride, was synthe-sized from piperazine hydrochloride via neutralization and condensation with 4,4'-difluorobenzhydrylchloride with an overallyield of 70.4%。

• 单位
  山东大学