New triterpenes from roots of Euphorbia kansui and their antioxidant activities [甘遂中的新三萜及其抗氧化活性]

作者：Ma L.; Wang J.-L.; Chai T.; Wang C.-B.; Meng X.-H.; Yang J.-L.^*

来源：Chinese Traditional and Herbal Drugs, 2022, 53(8): 2269-2273.

DOI：10.7501/j.issn.0253-2670.2022.08.001

• Antioxidant activity
• Euphane triterpene
• Euphokansuione A
• Euphol
• Euphorbia kansui S.L.Liou ex S.B.Ho
• Lanostane triterpene
• Potential neuroprotective activity
• Triterpenes

To isolate compounds from the roots of Euphorbia kansui and investigate their antioxidant activities. Methods: Various column chromatography techniques were used to isolate and purify the compounds and their structures were identified by spectral data. Meanwhile, the isolated compounds were evaluated for antioxidant activity in SH-SY5Y cells. Results: Five triterpenes were isolated and identified from the methanol extract of the roots of E. kansui, including three euphane triterpenes, namely eupha-8,24-diene-3β-ol-7,11-dione (1), (24R)-eupha-8,25-diene-3β,24-diol (2), euphol (3), and two lanostane triterpenes namely 3β,11β-dihydroxylanosta-8,24-dien-7-one (4), 3β,7β-dihydroxylanosta-8,24-dien-11-one (5). Conclusion: Compound 5 is a new compound named euphokansuione A and compounds 1 and 4 are isolated from this plant for the first time. Compounds 2 and 5 have certain antioxidant capacity in SH-SY5Y cells and potential neuroprotective activity.

• 单位
  中国科学院; 中国科学院大学