Mielin車lise pontina central e extrapontina: relato de caso com evoluˋˋo catastr車fica

作者：Brito; Adriana Rocha; Vasconcelos; Marcio Moacyr; Cruz Junior; Luiz Celso Hygino da; Oliveira; Maria Emilia Domingues Costa Quaresma de; Azevedo; Adriana Rodrigues Miguel de; Rocha; Luciana da Graa Vieira; Mendona; Priscilla Costa

来源：Jornal de Pediatria, 2006.

DOI：10.1590/S0021-75572006000200014

• central pontine myelinolysis
• extrapontine myelinolysis
• osmotic demyelination
• hyponatremia
• magnetic resonance imaging
• adolescence.

objective: to report a pediatric case of central pontine and extrapontine myelinolysis, a rare neurological disease often associated with rapid correction of hyponatremia. description: a 15 year-old female adolescent developed locked-in syndrome during severe hyponatremia. brain magnetic resonance imaging was consistent with the diagnosis of central pontine and extrapontine myelinolysis. comments: serum sodium correction should proceed slowly and cautiously, based upon a careful calculation of sodium deficit, in order to minimize metabolic stress and avoid the occurrence of this dreadful complication, which has a tragic outcome in most cases. there is no scientifically proved effective treatment for myelinolysis, and severe cases usually have a dismal prognosis.