Catalytic Enantioselective Formal (4 2) Cycloaddition by Aldol–Aldol Annulation of Pyruvate Derivatives with Cyclohexane‐1,3‐Diones to Afford Functionalized Decalins

作者：Dr Pandurang V Chouthaiwale; Dr Ravindra D Aher; Prof Dr Fujie Tanaka

来源：Angewandte Chemie - International Edition, 2018, 57(40): 13298-13301.

DOI：10.1002/anie.201808219

• Aldol reactions
• Asymmetric catalysis
• Asymmetric synthesis
• Organocatalysis

Abstract(#br)The decalin structure is found in bioactive molecules. We have developed catalytic enantioselective formal (4 2) cycloaddition reactions via aldol–aldol cascade reactions between pyruvate‐derived diketoester derivatives and cyclohexane‐1,3‐dione derivatives that afford highly functional...