Forˋa muscular como determinante da efici那ncia do consumo de oxig那nio e da m芍xima resposta metab車lica ao exerc赤cio em pacientes com DPOC leve/moderada

作者：Muller; Paulo de Tarso Guerrero; Viegas; Carlos Alberto de Assis; Patusco; Luiz Armando Pereira

来源：Jornal Brasileiro de Pneumologia, 2012.

DOI：10.1590/S1806-37132012000500002

• respiratory function tests
• pulmonary disease
• chronic obstructive
• muscle strength
• oxygen consumption.

objective: to compare the behavior of the oxygen uptake efficiency slope (oues) with that of oxygen uptake at peak exertion (vo2peak). methods: this was a prospective cross-sectional study involving 21 patients (15 men) with mild-to-moderate copd undergoing spirometry, handgrip strength (hgs) testing, cardiopulmonary exercise testing, and determination of lactate at peak exertion (lacpeak). results: mean weight was 66.7 ㊣ 13.6 kg, and mean age was 60.7 ㊣ 7.8 years. with the exception of fev1 and fev1/fvc ratio (75.8 ㊣ 18.6 of predicted and 56.6 ㊣ 8.8, respectively), all spirometric variables were normal, as was hgs. the patients exhibited significant metabolic and hemodynamic stress, as evidenced by the means (% of predicted) for vo2peak (93.1 ㊣ 15.4), maximum hr (92.5 ㊣ 10.4), and oues (99.4 ㊣ 24.4), as well as for the gas exchange rate (1.2 ㊣ 0.1). the correlation between vo2peak and oues was significant (r = 0.747; p %26lt; 0.0001). the correlation between hgs and vo2peak (r = 0.734; p %26lt; 0.0001) was more significant than was that between hgs and oues (r = 0.453; p %26lt; 0.05). similar results were found regarding the correlations of vo2peak and oues with mip. although lacpeak correlated significantly with vo2peak (r = -0.731; p %26lt; 0.0001), only lacpeak/maximum power correlated significantly with oues (r = -0.605; p = 0.004). conclusions: our findings suggest that, in mild-to-moderate copd, vo2 determinants other than overall muscle strength have a greater impact on oues than on vo2peak.