科研之友
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摘要
Introduction. Technetium-99m (99mTc) is the radionuclide most widely used in nuclear medicine. Its use on diagnostic allows imaging of anatomical structure and provides information on body functions.The radionuclide large demand is due to its desirable nuclear properties, the huge amount of 99mTc-labelled compounds and the existence of generators which make 99mTc available far from any production centre.A radionuclide generator is a system by which the parent, an unstable nucleus, produces by radioactive decay a radioactive daughter of shorter half live. In the case of 99mTc generators the parent is Molybdenum (99Mo) with 66 h half life, while the product 99mTc is 6 h half life.Objectives. The Radioisotope Production Laboratory from Chilean Nuclear Energy Commission, CCHEN, delivers, on a daily base, 99mTc to nuclear medicine centers located in the Metropolitan Region (MR). The Laboratory is unable, however, to deliver activities to other country%26apos;s centers far from MR because its production process. To resolve this situation, CCHEN decided to initiate a project to manufacture and deliver 99Mo - 99mTc generators. With this, in the near future, Chile will be part of the international community managing this technology.Materials and Methods. The manufacturing process is based on selective adsorption of 99Mo on aluminium oxide (Al2O3) whereas weakly bounded 99mTc, produced by 99Mo decay, is easily on a daily basis eluted from alumina. This generator is easy to operate being produced in a closed system designed to warrant sterility and a high purity product.Results and Conclusions. The alumina preparation, Mo conditioning and the columns characteristics are determinant factors in the manufacturing of 99mTc-Generators. With the alumina treatment retention of 99Mo near to 90% has been achieved. The 99mTc elution efficiency, in the form of pertechnetate (TcO-4), is over 80%. Based on these results, a preproduction batch and the subsequent production of 99mTc generators is expected to by the end of last quarter of 2004.Introducci車n. El Tecnecio-99m (99mTc) es el radiois車topo m芍s utilizado en medicina nuclear. Su uso en diagn車stico permite visualizar im芍genes de estructuras anat車micas y brindar informaci車n sobre distintas funciones org芍nicas.La gran demanda de este radionucle赤do se debe a sus favorables propiedades nucleares, a la gran cantidad de compuestos que se pueden marcar con 谷l y al hecho de poder contar con generadores de 99mTc, lo que posibilita su obtenci車n en lugares alejados de los centros de producci車n.Un generador de radiois車topos es un sistema medi
