Role of ABCA1 in angiotensin Ⅱ-induced cholesterol accumulation in podocytes

作者：杨简

来源：China Medical Abstracts Internal Medicine, 2018, 35(02): 115.

<正>Objective To investigate the effects of angiotensinⅡ(AngⅡ)on the expression of ATP-binding cassette transporter A1(ABCA1)in AngⅡ-infused rat model and cultured human podocytes,and to explore the role of ABCA1 in AngⅡ-induced cholesterol accumulation of podocytes.Methods Twelve Wistar rats were randomly subjected to normal saline infusion,or AngⅡinfusion at400 ng·kg-1·min-1(via subcutaneous osmotic minipumps)for 8 weeks.The expression of glomerular

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  武汉大学