Brønsted acid promoted one-pot synthesis of 4-aryl-3,4-dihydrocoumarins

作者：Cheng Chen; Rui Zhang; Long Lin; Guang-Fu Yang; Qiong-You Wu

来源：Tetrahedron, 2016, 72(27–28): 3917-3921.

• Dihydrocoumarins
• Friedel–Crafts alkylation
• Cycloaddition
• Brønsted acid
• Perchloric acid

4-Aryl-3,4-dihydrocoumarins are a class of valuable molecules demonstrating attractive pharmaceutical and biological properties. In this paper, we designed a new and facile approach to synthesis of 4-aryl-3,4-dihydrocoumarin derivatives by Brønsted acid catalyzed Friedel–Crafts alkylation and cycloaddition reaction. With this protocol, 15 examples of 4-aryl-3,4-dihydrocoumarins were successfully prepared with yields ranging from 82 to 99%.