Synthesis of 3‐Methylidene‐1‐tosyl‐2,3‐dihydroquinolin‐4(1 H )‐ones as Potent Cytotoxic Agents

作者：Jacek Koszuk; Tomasz Bartosik; Jakub Wojciechowski; Wojciech M Wolf; Anna Janecka; Joanna Drogosz; Angelika Dugosz; Urszula Krajewska; Marek Mirowski; Tomasz Janecki

来源：Chemistry and Biodiversity, 2018, 15(9): e1800242.

DOI：10.1002/cbdv.201800242

• 3‐methylidenequinolin‐4‐ones
• Horner–Wadsworth–Emmons olefination
• Resonance‐assisted hydrogen bond
• Cytotoxic evaluation

An efficient synthetic strategy to 3‐methylidene‐2,3‐dihydroquinolin‐4(1 H )‐ones variously substituted in position 2 has been developed. The title compounds were synthesized in the reaction sequence involving reaction of diethyl methylphosphonate with methyl 2‐(tosylamino)benzoate, condensation of ...