Development of a dried blood spot HPLC‐PDA method for the analysis of linezolid and ciprofloxacin in hospital‐acquired pneumonia patients

作者：Vincenzo Ferrone; Maura Carlucci; Roberto Cotellese; Paolo Raimondi; Annadomenica Cichella; Lorenzo Di Marco; Salvatore Genovese; Giuseppe Carlucci

来源：Drug Testing and Analysis, 2017, 9(10): 1611-1619.

DOI：10.1002/dta.2195

• Linezolid
• Ciprofloxacin
• Dried blood spot
• Method validation
• HPLC‐PDA

This study developed a high performance liquid chromatography (HPLC) method involving dried blood spotting (DBS) as a sampling method for the therapeutic drug monitoring of antimicrobial combination therapy with linezolid and ciprofloxacin. DBS for standards, quality control samples, and patient sam...