Vulvovaginal candidiasis: A review

作者：Amouri I; Abbes S; Sellami H; Makni F; Sellami A; Ayadi A^*

来源：Journal de Mycologie Medicale, 2010, 20(2): 108-115.

DOI：10.1016/j.mycmed.2010.01.005

• Vulvovaginal candidiasis
• Epidemiology
• Pathogenesis
• Diagnostic
• Treatment

Vulvovaginal candidiasis is a yeast infection that affects a large proportion of childbearing age women. Recurrent vulvovaginal candidiasis remains a common problem affecting women's well-being. Candida spp., especially C. albicans a commensal organism of the vaginal mucosa, is responsible for the pathogenesis of vulvovaginal candidiasis. The development of Candida vaginitis involves some breakdown of a balance between an aggressive fungal traits and host active immune surveillance that allows Candida growth and mucosal colonization. Despite a growing list of risk factors, a partial understanding of anti Candida host defense mechanism and Candida virulence factors, pathogenesis of vulvovaginal candidiasis continue to elude us. The management of this vaginitis needs a good understanding of its pathogenesis to concept an efficient antifungal treatment and to progress in the generation of new therapeutic strategies.