科研之友
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摘要
objective: eosinophilia and increased serum ige levels are indicators of atopy; however, other factors can also play a key role, such as intestinal parasitic infections. this study assesses the relationship between total serum ige, eosinophil count, and anti-ascaris ige in individuals with asthma and/or allergic rhinitis. methods: a cross-sectional study was carried out in adolescents with asthma and/or allergic rhinitis. the patients had their total serum ige, anti-ascaris ige and eosinophil count measured. results: a total of 101 patients aged 12 to 21 years were assessed. median ige level was 660 iu/ml (p25-75 243.5-1500), and the eosinophil count corresponded to 510 cells/mm3 (p25-75 284-811). anti-ascaris ige was positive in 73% (74/101) of the individuals, but parasitological stool examination yielded positive results in only 33.7% (34/101). the correlation coefficients were the following: 0.34 (p = 0.001) between total ige level and eosinophil count, 0.52 (p %26lt; 0.001) between total ige level and anti-ascaris ige, and 0.26 (p = 0.01) between eosinophil count and anti-ascaris ige. the final multiple linear regression model pointed out that anti-ascaris ige contributed to a total serum ige level with a coefficient of determination (adjusted r2) of 0.25 (f = 12.35; p %26lt; 0.001). this effect occurred regardless of eosinophil count and of the presence of intestinal helminthic infection. conclusion: in patients with respiratory allergy and increased total serum ige levels living in areas where there is a high risk for helminthic infections, the quantification of anti-ascaris ige can be more useful and more insightful than the parasitological stool examination.
