污汛 T cells and IL-17/IL-17R signaling axis in CNS inflammation

作者：Jayasri Das Sarma

来源：International Journal of Interferon, Cytokine and Mediator Research, 2010.

DOI：http://dx.doi.org/10.2147/IJICMR.S7066

• cytokine
• &gamma
• &delta
• T cells
• TH17 cells
• IL-17
• IL-17R
• multiple sclerosis
• EAE
• autoimmunity
• CNS
• viral infection
• virus-induced demyelination

ells and IL-17/IL-17R signaling axis in CNS inflammation Review (3193) Total Article Views Authors: Jayasri Das Sarma Published Date November 2010 Volume 2010:2 Pages 149 - 155 DOI: http://dx.doi.org/10.2147/IJICMR.S7066 Jayasri Das Sarma Department of Biological Sciences, Indian Institute of Science Education and Research 每 Kolkata, Mohanpur, Nadia, West Bengal, India Abstract: Lymphocytes expressing 污汛 T-cell receptors constitute an entire system of functionally specialized subsets that have been implicated in the regulation of immune responses, including responses to pathogens and allergens, and in tissue repair. 污汛 T cells represent a small subpopulation of T cells that, unlike a汕 T cells, function more as cells of the innate immune system. 污汛 T cells are known to mediate the production of inflammatory cytokines, including interferon-污, tumor necrosis factor-a, and interleukin (IL)-17, and thus enable the activation of other subsets of infiltrating effector cells. However, not much attention was paid to 污汛 T cells until the recent discovery of a distinct CD4+ T helper (TH) cell, TH17 cell. CD4+ T cells, upon activation and expansion, develop into different TH-cell subsets with different cytokine profiles and distinct effector functions. T cells were earlier divided into TH1 or TH2 cells, depending on the cytokines they produce. A third subset of IL-17-producing effector TH cells, called TH17 cells, has been discovered and characterized recently. Since then the literature on IL-17-producing cells has grown steadily, and several studies have focused on 污汛 T cells. Cytokine-mediated modulation of central nervous system (CNS) inflammatory diseases by 污汛 T cells in humans or in animal models is currently the subject of many studies. IL-17 and its receptor IL-17R have been implicated in the pathogenesis of immune-mediated CNS diseases, and attention has been paid to understand the mechanisms by which IL-17 cytokines and it receptor (IL-17R) family mediate the effects at a molecular level. This article reviews the studies that cover earlier aspects of 污汛 T cell/IL-17 biology and the new dimension of 污汛 T cells, IL-17, and IL-17/IL-17R signaling axis in CNS inflammation. Understanding the role of 污汛 T cells, IL-17, and IL-17/IL-17R signaling axis in infection and immunity could open a new avenue for immunomodulation.