Correlaˋˋo entre a resist那ncia a pirazinamida e a resist那ncia a outros f芍rmacos antituberculose em cepas de Mycobacterium tuberculosis isoladas em um hospital de refer那ncia

作者：Fonseca; Leila de Souza; Marsico; Anna Grazia; Vieira; Gisele Betzler de Oliveira; Duarte; Rafael da Silva; Saad; Maria Helena Feres; Mello; Fernanda de Carvalho Queiroz

来源：Jornal Brasileiro de Pneumologia, 2012.

DOI：10.1590/S1806-37132012000500013

• tuberculosis [drug therapy]
• tuberculosis [microbiology]
• antibiotics
• antitubercular.

the correlation between resistance to pyrazinamide (pza) and resistance to other first-line antituberculosis drugs was investigated in 395 mycobacterium tuberculosis strains isolated from clinical specimens, representing 14% of the overall number of m. tuberculosis isolates obtained between 2003 and 2008 at the laboratory of a referral university hospital for tuberculosis. a high correlation was found between resistance to pza and multidrug resistance, as well as between pza resistance and resistance to rifampin, isoniazid, and ethambutol (p %26lt; 0.01 for all). these results highlight the importance of performing pza susceptibility testing prior to the prescription of this drug in order to treat drug-resistant and multidrug-resistant tuberculosis.