Age-, season- and gender-specific reference intervals of serum 25-hydroxyvitamin D₃ for healthy children (0 ～ 18 years old) in Nanning area of China

作者：Zhou, Dong-yi; Wei, Shang-mou; Zhu, Chun-ling; Wei, Yu-hong; Wang, Xiao-mei; Yi, Li-ling; Yang, Si-tao; Peng, Qi-liu^*

来源：Journal of Physiological Sciences, 2024, 74(1): 2.

DOI：10.1186/s12576-023-00895-z

• Reference intervals (RIs)
• 25-hydroxyvitamin D-3 [25(OH)D
• Vitamin D
• Children

Establishing specific reference intervals (RIs) of serum 25-hydroxyvitamin D3 [25(OH)D] for children is essential for improving the accuracy of diagnosis and prognosis monitoring of diseases such as rickets and growth retardation. The study including 6,627 healthy children was conducted to establish specific RIs of 25(OH)D for children in Nanning area of China. The results showed that there were statistically significant differences among age, season, and gender of serum 25(OH)D levels, and the age-specific RIs of serum 25(OH)D were 20.3 similar to 53.6 ng/mL for 0 similar to <= 1 year and 18.9 similar to 49.6 ng/mL for 2 similar to <= 3 years. The age-, season-specific RIs of serum 25(OH)D for 4 similar to <= 6 years in spring-summer and autumn-winter were 15.8 similar to 42.6 ng/mL and 15.2 similar to 37.7 ng/mL, respectively. The age-, gender-specific RIs of serum 25(OH)D for 7 similar to <= 18 years for males and females were 12.1 similar to 36.1 ng/mL and 10.8 similar to 35.3 ng/mL, respectively. This study successfully established the RIs of serum 25(OH)D, which may help to improve disease diagnosis and monitoring for children in the Nanning area of China.

• 单位
  广西中医药大学