科研之友
微信
新浪微博
Facebook
分享链接
摘要
A novel complex of lanthanum(Ⅲ) with demethylcantharidate group (DCA), Na[La(DCA)_2(H_2O)], was synthesized in aqueous solution and characterized by elemental analysis, molar conductance, IR, UV, ~1H-NMR spectra and TG-DTA. The results suggest that lanthanum ion is seven-coordinated. Six oxygen atoms are from carboxyl groups and cyclic ethers of two DCA ligand, and on oxygen is from a H_2O. The antitumor activities of the complex against HL-60 human leukemia, BGC-823 human gastric carcinoma, Bel-7402 human hepatic carcinoma, Hela human cervical carcinoma were investigated with MTT or SRB assays. Na[La(DCA)_2(H_2O)] exhibits stronger inhibition against certain kinds of cancer cells than Na_2DCA in vitro.
- 单位
