科研之友
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摘要
Lead is one of the heavy metals most used in industry. Poisoning due to long-term lead exposure is known as saturnism, and is an occupational illness that has been known for many years. Lead is highly toxic and can compromise the structural and functional patterns of organs and systems. The aim of this study was to examine the lungs and kidneys of fetuses from female Wistar rats exposed to lead acetate. In this study, the lungs and kidneys of 20 fetuses from female rats that had previously been treated with lead acetate were dissected, fixed, embedded in paraffin and stained with hematoxylin and eosin. Macroscopic changes to the shape, color and consistency of organs from fetuses treated with this heavy metal were observed, in comparison with organs from control fetuses. Microscopic lesions characterized by vascular sclerosis, cell atrophy or hyperplasia, progressive interstitial fibrosis, inclusion bodies containing lead acetate and glomerular sclerosis were found in the kidneys. The lesions found in the lungs consisted of destructuring of the parenchyma, impregnation with lead acetate, formation of fibrosis, extravasation of vascular fluids, reduction of the alveolar spaces and formation of alveolar edema. These changes were correlated with the level of lead acetate absorption, as determined using atomic spectrophotometry. El plomo es un metal pesado utilizado en la industria. El envenenamiento debido a la exposici車n prolongada por plomo es una enfermedad profesional conocida por muchos a os. La toxicidad del plomo es muy expresiva y puede poner en peligro el modelo estructural y funcional de los 車rganos y sistemas. El objetivo de este estudio fue examinar los pulmones y ri ones de fetos de ratas Wistar expuestos al acetato de plomo. En este estudio, 20 fetos de ratas Wistar previamente tratados con acetato de plomo durante la gestaci車n, tuvieron sus 車rganos disecados, fijados, incluidos en parafina y te idos con hematoxilina y eosina. Macrosc車picamente, los 車rganos fetales tratados por este metal fueron comparados con los 車rganos de fetos controles en relaci車n a forma, color y consistencia. Microsc車picamente, se encontraron lesiones en el ri 車n que se caracterizaron por esclerosis vascular, atrofia o hiperplasia de c谷lulas, fibrosis intersticial progresiva, presencia de cuerpos de inclusi車n que conten赤an acetato de plomo y esclerosis glomerular. En el pulm車n se observ車 desorganizaci車n del par谷nquima impregnado con acetato de plomo, formaci車n de fibrosis, l赤quido intersticial, reducci車n de los espacios alveolares y edema alveolar. Estos cambios se cor
