科研之友
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摘要
Objective:To analysis the levels of serum renin (PRA),angiotensin I (AngI),angiotensin II (AngII)and aldosterone (Ald)in patients at different ages with essential hypertension in wuhan.Method:600 cases who were clinically diagnosed as essential hypertension,and all of patients were divided into three groups according to the degree of hypertension and the age respectively.namely,the patients were divided as ≤50 years old group (n=205),from 5 1 to 65 years old group (n=1 91),> 65 years old group (n=204)by age,and they were divided by the degree of hypertension as grade 1 group (n=204),grade 2 group (n=1 97)and grade 3 group (n=1 99),120 cases of healthy as control group.The values of PRA,AngI,AngII and Ald were measured,and the differences a-mong groups at different ages and in different degrees of hypertension were comparatively analysised and the correla-tions between Ang,Ald and the of hypertension were also analyzed.Results:There were no significant differences in the levels of PRA,Ang I,Ang II and Ald between the different age groups and the control group and the different age groups (P > 0.05).There was no significant difference in the levels of PRA (P > 0.05);The levels of Ang I and Ang II in grade 2 and 3 hypertension groups were significantly higher than control group (P <0.05),and the values of Ang I and Ang II in grade 3 hypertension group was significantly higher than grade 1 hypertension group (P <0. 05).Compared with the healthy control group,the level of Ald in Grade 1,2,3 hypertension groups was significantly higher (P <0.05).There were significantly positive correlations among Ald and Ang I in patients with severe hypertension(r=0.184 and 0.139 respectively).Conclusion:The levels of Ang and Ald in patients with essential hypertension were re-lated to the severity of hypertension,but not the ages of patients.
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