Incid那ncia de epis車dios hipotˋnicos-hiporresponsivos associados 角 vacina combinada DTP/Hib usada no Programa Nacional de Imunizaˋˋes

作者：Martins; Reinaldo M; Camacho; Luiz A B; Lemos; Maria Cristina F; Noronha; Tatiana G de; Carvalho; Maria Helena C de; Greffe; Nadja; Silva; Marli M da; Perisse; Andre R; Maia; Maria de Lourdes S; Homma; Akira

来源：Jornal de Pediatria, 2007.

DOI：10.1590/S0021-75572007000800008

• active surveillance
• hypotonic-hyporesponsive episodes
• dtwp/hib vaccine
• safety.

objective:to evaluate the safety of a combined diphtheria-tetanus-whole cell pertussis-haemophilus influenzae type b vaccine used on the brazilian national immunizations program, chiefly the incidence of hypotonic-hyporesponsive episodes. method: follow-up of a cohort of 21,064 infants (20,925 or 99.7% adhered to the study protocol), within 48 hours of vaccination with diphtheria-tetanus-whole cell pertussis-haemophilus influenzae type b vaccine in health care units in the city of rio de janeiro, to ascertain and investigate spontaneous and solicited severe adverse events. each child was followed-up for one dose only. results: the rate of hypotonic-hyporesponsive episodes was 1/1,744 doses (confirmed cases) and 1/1,495 doses (confirmed plus suspect cases). the rate of convulsions was 1/5,231 doses. no cases of apnea were detected. these results are comparable to those found in the literature with diphtheria-tetanus-whole cell pertussis vaccine. conclusion: the diphtheria-tetanus-whole cell pertussis-haemophilus influenzae type b vaccine under study can be safely used in the national immunizations program, according to the current precautions and contraindications.