科研之友
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摘要
In developing countries, herbal medicines have continued to remain significant and readily patronized. Numerous plants have been used historically to reduce fertility and modern scientific research has confirmed antifertility effect in some of the herbs tested. To investigate the effects of Abrus precatorius (AP) on the histology of the ovary, oviduct and uterus of female Sprague-Dawley (S-D) rat. A total of 40, 6-8 week old 4-day cycling female S-D rats were used. They were divided into the treatment, control and reversibility groups. The treatment and reversibility groups were fed oral AP seed extract (50 mg/kg b.w) for 32 days. A fraction of the rats in reversibility group was treated with distilled water for another 32 days. The control group were used to compare events in the other groups. At the end of the experimental durations animals were sacrificed under light chloroform anesthesia. Their ovaries, uteri and oviducts harvested for microscopic studies. Comparing the control histological sections to the treated groups: the ovaries showed decreased size, large follicular distension and extensive stromal necrosis with compromised cellularity. The uterine tubes revealed appreciable mucosal reduction. The uteri exhibited reduction in the layer of endometrial thickness. On the other hand sections in reversal experimental rats were comparable to control. The rats treated with AP seed extract at dose 50 mg/kg b.w induced reversible alterations in ovaries, uterine and uteri in S-D. En los pa赤ses en desarrollo, las hierbas medicinales siguen siendo de gran importancia y de f芍cil utilizaci車n. Numerosas plantas se han utilizado hist車ricamente para reducir la fertilidad y la investigaci車n cient赤fica moderna ha confirmado el efecto anti-fertilidad en algunas de las hierbas estudiadas. Para investigar los efectos de Abrus precatorius (AP) sobre la histolog赤a del ovario, oviducto y 迆tero de ratas Sprague-Dawley (SD), fueron utilizadas un total de 40 ratas SD hembras de 6-8 semanas de edad en el d赤a 4 del ciclo. Se dividieron en grupos de tratamiento, control y reversibilidad. Los grupos de tratamiento y reversibilidad se alimentaron por v赤a oral con el extracto de semilla de AP (50 mg/kg de peso corporal) durante 32 d赤as. Una fracci車n de las ratas del grupo de reversibilidad se trat車 con agua destilada durante otros 32 d赤as. El grupo de control se utiliz車 para comparar los eventos en los otros grupos. Al finalizar el periodo experimental los animales fueron sacrificados bajo anestesia con cloroformo. Los ovarios, 迆tero y los oviductos fueron procesados para los
