科研之友
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摘要
Objective: To evaluate the effect of Chinese herbal medicine formula, modified Liujunzi Decoction(六君子汤, MLJZT), for anorexia, utilized as adjunct therapy during chemotherapy treatment for patients with advanced non-small cell lung cancer(NSCLC). Methods: The study adopted a propensity score-matched design based on a prospective database. From February 2016 to September 2017, patients with advanced NSCLC that received both cisplatin-based chemotherapy and MLJZT(IM group) were 1:1 propensity score-matched to patients that received the cisplatin-based chemotherapy alone(control group). Changes in anorexia and weight, as well as side effects were evaluated per week within 4-cycle chemotherapy. Results: Overall, 156 patients with advanced NSCLC that had received chemotherapy from our database were identified and 53 pairs were matched successfully. In total, 48.6%(50/53) of patients in the IM group had anorexia-improvement compared to 28.3%(15/53) of patients in the control group, and a total of 39.6%(21/53) of patients in the control group had a worsening of anorexia compared to only 7.8%(8/53) of patients in the IM group(P<0.01). The weight reduced significantly over time in the control group(–2.36±2.53 kg) as compared to the IM group(–0.62±3.89 kg, P<0.01). CHM didn’t reduce the efficacy of chemotherapy in shrinking tumor size, and didn’t increase the incidence of side effects such as hematological and hepatorenal toxicity. Conclusion: MLJZT is effective and safe for alleviating anorexia in patients with NSCLC. These findings warrant the conduct of a randomized controlled trial.
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