科研之友
微信
新浪微博
Facebook
分享链接
摘要
To explore the dynamic changes of body weightㄛskin and activities of antioxidant-enzyme in liver and kidney of developing filial mice after irradiation with different dosages of X-rayㄛprovide a basis for prevention and cure of irradiationㄛthe effect of different dosages (0.0ㄛ0.5ㄛ2.0ㄛ3.5ㄛ5.0ㄛ6.5 Gy) of X-ray on activity and content of Superoxide dismutaseㄗSODㄘㄛCatalase (CAT)ㄛand Maleic dialdehyde (MDA) in liver and kidney of developing filial mice(1 dㄛ5 dㄛ10 dㄛ20 d) were determined by colorimetry. The results showed that the body weight of filial mice decreased after irradiation with 2.0﹜3.5﹜5.0 and 6.5 Gy of X-ray. Skins started to be denuded of hairs 3 d after irradiation with 3.5ㄛ5.0 and 6.5 Gy of X-ray but the new hairs resurged at 10 d. Purple spot appeared in the skin of 6.5 Gy group filial mice. SOD activity in 0.5 Gy group filial mice increased in the early time after irradiationㄛsubsequently decreased to the normal level gradually. In other groupsㄛSOD activity decreased firstly and then increased slowlyㄛbut it was always lower than the control group. MDA content in 0.5 Gy group filial mice decreased in the early timeㄛthen increased to the normal level slowly. In other groupsㄛit obviously increased firstly and then decreased slowlyㄛbut always higher than the control group. CAT activity in 0.5ㄛ2.0 Gy groups filial mice decreased in the early timeㄛthen increased. Howeverㄛin other groups the activity increased in the early time and decreased in the following days. There was a trend that the activity and content of target enzyme in liver and kidney recovered slowly to the normal level after irradiation. The irradiation of X-rays affects the weightㄛskin and activity of antioxidant-enzyme in liver and kidney of developing filial mice significantly. And the dosages contributed more to the damage effect than treatment time. In shortㄛ large dosages of irradiation would cause disadvantageous effect on developing filial mice[Acta Zoologica Sinica 54(6): 1029 每 1037, 2008].
