摘要

目的:探讨不同剂量阿托伐他汀对颈动脉狭窄(CAS)支架植入术后再狭窄的预防作用。方法:将我院收治的86例行支架植入术的CAS患者按随机数字表法分为大剂量组(阿托伐他汀20 mg/d)和小剂量组(阿托伐他汀10 mg/d),各43例,均治疗12个月,比较两组治疗效果。结果:治疗后大剂量组CAS改善情况优于对照组,差异有统计学意义(P <0.05);大剂量组脑卒中复发率低于小剂量组,差异有统计学意义(P <0.05);治疗后大剂量组改良的RANKIN量表(mRS)评分小于小剂量组,差异有统计学意义(P <0.05);治疗后大剂量组血白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α、丙二醛(MDA)及氧化修饰低密度脂蛋白(ox-LDL)水平低于小剂量组,差异有统计学意义(P <0.05)。结论:高剂量阿托伐他汀可有效预防CAS患者支架植入术后再狭窄的发生,促进神经功能恢复,减少炎症反应。

  • 单位
    神经内科

36

被引

Technology development
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Molecular & Cellular Proteomics, 2011, 10(2): E110.007468.
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Xu Heng*; Teo Hock Hai; Tan Bernard C Y; Agarwal Ritu
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474

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Technology Development Continuum
Sternberger Wayne I*
Marine Technology Society Journal, 2015, 49(3): 30-33.
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Fast pyrolysis technology development
Venderbosch R H*; Prins W
Biofuels Bioproducts & Biorefining-Biofpr, 2010, 4(2): 178-208.

393

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Astronomy, technology development and industry
Vigroux Laurent
260th Symposium of the International-Astronomical-Union, 2009-01-19 to 2009-01-23.
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Research on Technology Development of High
Zhengyan Lu
Journal of Physics: Conference Series , 2020, 1549(5).
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An Analogical Induction Approach to Technology Standardization and Technology Development
Jiang, Hong; Zhao, Shukuan*; Yin, Kaiqi; Yuan, Yue; Bi, Zhuming
Systems Research and Behavioral Science, 2014, 31(3): 366-382.

8

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