科研之友
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摘要
Objective To investigate the antibiotic resistance spectrum and genetic characteristics of multidrug-resistant Staphylococcus aureus(MDRSA, nasal isolate among primary school students, and to provide a scientific basis for the prevention and control of masal MDRSA resistance and the selection of clincal drugs in children. Methods Antibiotic susceptibility experiments were performed on all SA isolates of 1 705 primary school students from 8 primary schools in Guangzhou selected by using multistage cluster stratified sampling method. MDRSA antibiotic susceptibility spectrum was analyzed, and the resistant, virulence and immune evasion cluster(IEC, genes detected by polymerase chain reaction(PCR. Results The prevalence of MDRSA nasal carriage was 20.76%(354/1 705, and the proportion of multidrug resistance among SA isolates was 96.20%(354/368. The predominant resistant antibiotics of MDRSA isolates were penicillin(99.72%, erythromycin(96.33%, clindamycin(90.96%, and teicoplanin(90.11%. Notably, 240(67.80%, 240/354, MDRSA isolates were resistant to more than six antimicrobial categories.And the predominant detection rates of resistant genes were BlaZ(92.66%, Tet(M, (49.72%, virulence genes Tst(25.42%, and IEC genes Sak(92.09%, Hlb(61.58%. Conclusion We found high prevalence of nasal colonization MDRSA from healthy children. Moreover, MDRSA isolates has a high resistant rate to multiple antibiotics, and the proportion of resistant to ≥6 antimicrobial categories is high. ? 2020 Journal Office of Chinese School Health(Bengbu).
