科研之友
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摘要
Programmed cell death (PDCD) is a kind of evolutionarily conserved protein related to tumor development. The PDCD family is composed of several members, among which PDCD1, PDCD2, PDCD4, PDCD5, PDCD6, PDCD7, PDCD9 and PDCD10 are studied more in-depth. PDCD is widely distributed in various tissues and cells of human, and its main function is to regulate apoptosis. At present, it is found that PDCD family members can regulate the activity of tumor cells through different signal pathways, and the absence or over-expression of some members can cause pathological changes in the body, which suggests that PDCD plays an important role in a variety of diseases. In this paper, the gene structure and protein structure of PDCD1, PDCD2, PDCD4, PDCD5, PDCD6, PDCD7, PDCD8, PDCD9, PDCD10, PDCD11 and PDCD12 are summarized. The relationships among PDCDs in the event of programmed cell death are introduced, and the regulation of PDCD family members reported in tumors and various diseases are summarized, so as to help researchers understand their role in apoptosis, and provide references for the treatment of tumor and related diseases. ? 2020 Chinese Society of Biochemistry and Molecular Biology, Peking University. All Rights Reserved.
