Asymmetric Synthesis of ( R )‐1‐Alkyl‐Substituted Tetrahydro‐?‐carbolines Catalyzed by Strictosidine Synthases

作者：Dr Desiree Pressnitz; Dr Eva‐Maria Fischereder; Dr Jakob Pletz; Christina Kofler; Lucas Hammerer; Katharina Hiebler; Dr Horst Lechner; Dr Nina Richter; Elisabeth Eger; Prof Dr Wolfgang Kroutil

来源：Angewandte Chemie, 2018, 130(33): 10843-10847.

DOI：10.1002/ange.201803372

• Asymmetrische Katalyse
• Biokatalyse
• Pictet-Spengler-Reaktion
• Strictosidin-Synthasen
• Tetrahydro-β-carboline

Abstract(#br)Stereoselective methods for the synthesis of tetrahydro‐?‐carbolines are of significant interest due to the broad spectrum of biological activity of the target molecules. In the plant kingdom, strictosidine synthases catalyze the C?C coupling through a Pictet–Spengler reaction of trypta...