STUDIES ON THE COMPOSITION AND STANDARDIZATION OF ※BAKUCHI OIL§, AN AYURVEDIC MEDICINAL OIL PREPARED FROM PSORALEA CORYLIFOLIA L. USED IN THE TREATMENT OF VITILIGO

作者：Abeysekera Ajita Mahendra; Gunaherath Kamal Bandara; Gunawardena Ajantha Rohinie; Jayaweera Champa Disala

来源：International Journal of Research in Ayurveda and Pharmacy, 2012.

• Psoralea corylifolia
• Bakuchi oil
• Psoralen
• Standardization
• Dehydroisopsoralidin.

※Bakuchi oil§ is Ayurvedic medicinal oil prepared from the dried fruits of Psoralea corylifolia L. (Fabaceae) and Sesame oil is used widely in the treatment of vitiligo in Sri Lanka. The standardization of the oil is important for its safe and effective clinical use. A method was developed to quantitatively extract psoralen, the major photoactive compound in the oil and quantify it by TLC fluorodensitometry. The precision of the method was 4.3% CV (n = 6). A TLC fingerprint of the oil highlighting six fluorescent secondary metabolites of Psoralea corylifolia (psoralen, isopsoralen, corylin, psoralidin, dehydroisopsoralidin and isobavachalcone) was also developed. Of these dehydroisopsoralidin is being reported for the first time from a natural source. Analysis of the oil indicates that Bakuchiol, a major secondary metabolite of Psoralea corylifolia is not incorporated into the medicinal oil.