Synthesis, Bioactivity and Crystal Structure Analysis of Novel Benzo[d]isothiazol-3(2H)-ones

作者：Wang Xiang-Hui; Lin Qiang^*; Yin Xue-Qiong; You Cheng-Hang; Yang Jian-Xin

来源：Chinese Journal of Structural Chemistry, 2012, 31(8): 1170-1174.

• benzo[d]isothiazol-3(2H)-one (BIT)
• crystal structure
• antimicrobial activity

Two compounds, 3-oxo-N-o-tolylbenzo[d]isothiazole-2(3H)-carboxamide (1) and N-(2-methoxyphenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide (2), were synthesized from the initial compound benzo[d]isothiazol-3(2H)-one (BIT) and characterized by H-1 NMR, IR and elemental analysis, respectively. The single crystals of compounds 1 and 2 were obtained and determined by X-ray diffraction analysis. The preliminary results of biological activity experiment show that some of the title compounds exhibited a favorable antimicrobial activity.

• 单位
  海南大学; 昆明理工大学; 海南师范大学