科研之友
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摘要
The present research work is aimed to synthesize a series of various substituted benzothiazole derivatives containing 7-chloro-6-fluoro-N (substituted hydrozones) - benzothiazole.Structures of compounds has been established by means of IR, 1H-NMR and elemental analysis. The compounds MIIIc, MIIIf and MIIIJ at dose 5 mg/kg and 10mg/kg body.wt were evaluated for anti-inflammatory activity using carragennan induced paw edema method. The selected compounds have shown significant anti-inflammatory activity as compared to the standard drug. Compound MIIIJ (10 mg/kg body weight) has shown more significant result when compared with standard drug.
