银-沸石掺杂羟基磷灰石镁合金涂层的生物活性、体外腐蚀行为和抗菌活性（英文）

作者：H.R.BAKHSHESHI-RAD; E.HAMZAH; A.F.ISMAIL; M.AZIZ; E.KARAMIAN; N.IQBAL

来源：Transactions of Nonferrous Metals Society of China, 2018, 28(08): 1553-1562.

• 镁合金
• 沸石
• 涂层
• 生物活性
• 腐蚀行为
• 抗菌活性

Mg-based alloys received significant attention for temporary implant applications while, their applications have been limited by high degradation rate. Therefore, silver-zeolite doped hydroxyapatite(Ag-Zeo-HAp) coating was synthesized on Ti O2-coated Mg alloy by physical vapour deposition(PVD) assisted electrodeposition technique to decrease the degradation rate of Mg alloy. X-ray diffraction(XRD) analysis and field emission scanning electron microscopy(FE-SEM) images showed the formation of a uniform and compact layer of Ag-Zeo-HAp with a thickness of 15 μm on the Ti O2 film with a thickness of 1 μm. The potentiodynamic polarization(PDP) and electrochemical impedance spectroscopy(EIS) tests indicated that corrosion resistance of Mg-Ca alloy was considerably increased by the Ag-Zeo-HAp coating. The bioactivity test in the simulated body fluid(SBF) solution showed that a dense and homogeneous bonelike apatite layer was formed on the Ag-Zeo-HAp surface after 14 d. Investigation of antibacterial activity via disk diffusion and spread plate methods showed that the Ag-Zeo-HAp coating had a significantly larger inhibition zone(3.86 mm) towards Escherichia coli(E. coli) compared with the Ti O2-coated Mg alloy(2.61 mm). The Ag-Zeo-HAp coating showed high antibacterial performance, good bioactivity, and high corrosion resistance which make it a perfect coating material for biomedical applications.镁基合金作为临时植入材料的应用受到了越来越多的关注,然而,由于其降解速率高,因此应用受到了限制。为了降低镁合金的降解速率,本文作者采用物理气相沉积(PVD)辅助电沉积技术在镀氧化钛(Ti O2)的镁合金上涂覆掺银-沸石羟基磷灰石(Ag-Zeo-HAp)涂层。X射线衍射(XRD)分析和场发射扫描电镜(FESEM)图片显示,在厚度约为1μm的二氧化钛薄膜上形成了均匀且致密的Ag-Zeo-HAp涂层,厚度约为15μm。动电位极化(PDP)和电化学阻抗谱(EIS)测试表明,通过Ag-Zeo-HAp涂层,Mg-Ca合金的耐腐蚀性大大提高。模拟体液(SBF)浸泡测试生物活性试验结果表明,在14 d后的Ag-Zeo-HAp表面上形成了一层致密且均匀的类骨磷灰石层。采用琼脂扩散法和平板涂布法对抗菌活性进行研究。结果表明,与Ti O2涂层的镁合金(2.61 mm)相比,Ag-Zeo-HAp涂层对大肠杆菌(E.coli)的抑制区(3.86 mm)明显增大。Ag-Zeo-HAp涂层具有良好的抗菌性能、良好的生物活性和耐腐蚀性,是生物医学应用的理想涂层材料。