科研之友
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摘要
objectives: to describe the clinical and laboratory characteristics of patients on long-term home oxygen therapy followed up by the home care program of hospital das cl赤nicas, school of medicine, universidade de sˋo paulo, during a period of 8 years; to compare groups with and without secondary pulmonary hypertension; and to estimate the cost of the program using oxygen concentrators versus oxygen cylinders provided by the hospital. methods: a descriptive, retrospective cohort study of patients on long-term home oxygen therapy followed up from 2002 to 2009 at the unit of pulmonology, children%26apos;s institute, hospital das cl赤nicas, school of medicine, universidade de sˋo paulo. results: we studied 165 patients, of whom 53% were male, with the following medians: age at the beginning of oxygen therapy - 3.6 years; duration of oxygen therapy - 7 years; and survival time after beginning of oxygen therapy - 3.4 years. the main diagnoses were: cystic fibrosis (22%), bronchopulmonary dysplasia (19%), and bronchiolitis obliterans (15%). of the 33 patients who underwent spirometry, 70% had severe obstructive lung disease. echocardiogram was performed in 134 patients; 51% of them had secondary pulmonary hypertension. there was a statistically significant association between pulmonary hypertension and need of higher oxygen flows (chi-square, p = 0.011), and between pulmonary hypertension and longer duration of oxygen therapy (logrank, p = 0.0001). there was no statistically significant difference between survival time after the beginning of oxygen therapy and pulmonary hypertension. the average monthly costs of the program were us$ 7,392.93 for concentrators and us$ 16,630.92 for cylinders. conclusions: long-term home oxygen therapy was used to treat different chronic diseases, predominantly in infants and preschool children. there was a high frequency of pulmonary hypertension associated with longer periods of oxygen use and greater oxygen flow, without association with survival
