Synergistic Anticancer Therapy by Ovalbumin Encapsulation‐Enabled Tandem Reactive Oxygen Species Generation

作者：Jiang Shuai; Xiao Ming; Sun Wen; Crespy Daniel; Mailänder Volker; Peng Xiaojun; Fan Jiangli; Landfester Katharina

来源：Angewandte Chemie, 2020, 132(45): ange.202006649.

DOI：10.1002/ange.202006649

• cisplatin
• Fenton reactions
• hypoxic
• photodynamic therapy
• synergistic

Abstract The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O2.− produced by the PDT is converted to H2O2 by superoxide dismutase, followed by the transformation of H2O2 to the highly toxic .OH via Fenton reactions by Fe2+ originating from the dissolution of co‐loaded Fe3O4 nanoparticles. The PDT process further facilitates the endosomal/lysosomal escape of the active agents and enhances their intracellular delivery to the nucleus—even for drug‐resistant cells. Cisplatin generates O2.− in the presence of nicotinamide adenine dinucleotide phosphate oxidase and thereby improves the treatment efficiency by serving as an additional O2.− source for production of .OH radicals. Improved anticancer efficiency is achieved under both hypoxic and normoxic conditions.

• 单位
  Max Planck Institute for Polymer Research; 精细化工国家重点实验室; Johannes Gutenberg-University Mainz