miR‐134 targets PDCD7 to reduce E‐cadherin expression and enhance oral cancer progression

作者：Shih‐Yuan Peng; Hsi‐Feng Tu; Cheng‐Chieh Yang; Cheng‐Hsien Wu; Chung‐Ji Liu; Kuo‐Wei Chang; Shu‐Chun Lin

来源：International Journal of Cancer, 2018, 143(11): 2892-2904.

DOI：10.1002/ijc.31638

• Carcinoma
• E‐cadherin
• MiRNA
• PDCD7

Oral squamous cell carcinoma (OSCC) is a common malignancy worldwide. This study clarified the oncogenic role of miR‐134 in OSCC. Reporter assays, using both wild‐type and mutant constructs, confirmed that Programmed Cell Death 7 ( PDCD7) gene was a potential target of miR‐134 . The OSCC cells exoge...