新的手性膦配体的合成及其在苯乙烯不对称氢酯基化中的应用

作者：陈敏东; 郑有飞; 徐建强; 孙伟; 吕士杰; 华维一

来源：化学研究与应用, 2004, (01): 131-132.

• 手性膦配体
• 氢酯基化反应
• 催化剂

Two new chiral phosphine ligands,1,4∶3,6-dianhydro-2,5-O-dideoxy-2,5-bis(dipheny-phosphinoxy)-L-iditol and 1,4∶3,6-dianhydro-2,5-O-dideoxy-2,5-bis(dipheny-phosphinsulphur)-L-iditol were prepared from D-mannitol.Palladium catalytic systems formed with these ligands in situ were used as asymmetric homogenous catalysts for hydroesterification of styrene,giving(R)-2-phenyl propionate in 16.9 and 9.2% ee values,respectively.

• 单位
  中国科学院兰州化学物理研究所; 中国药科大学; 南京气象学院; 羰基合成与选择氧化国家重点实验室