Protective Effect of Effective Composite of Chinese Medicine Prescription Naodesheng(脑得生) against Focal Cerebral Ischemia in Rats

作者：张莉; 程新锐; 陈若芸; 竺晓鸣; 杜冠华

来源：Chinese Journal of Integrative Medicine, 2009, 15(05): 377-383.

• effective composite
• Naodesheng
• ischemia
• neuro-protection
• apoptosis

<正>Objective:To study the effects and possible mechanisms of effective composite of Naodesheng (脑得生,NDS) on permanent cerebral ischemia-induced injury in rats.Methods:Male Sprague-Dawley rats with middle cerebral artery occlusion(MCAO) were established with the modified suture method,and they were randomly divided into the following groups:the sham-operated group,the model group,the Nimodipine group(0.012 g/kg),the NDS group(1.075 g/kg),the total extracts group(0.23 g/kg),the high-dose NEC group (0.07 g/kg),the middle-dose NEC group(0.02 g/kg),and the low-dose NEC group(0.007 g/kg).The aforesaid medicines were administered at the 2nd,4th,and 24th h after focal cerebral ischemia,and the infarction size and water content in the brain were evaluated at the 26th h after MCAO.Then,after oral administration once daily for 7 successive days,the changes in the degree of neurological deficit,oxidative stress,and apoptosis were measured on the 7th day.Results:NEC could significantly reduce the infarction size after foc...

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  北京协和医学院