Synthesis of polysubstituted pyrroles via a gold(Ⅰ)-catalyzed tandem three-component reaction at room temperature

作者：Li Li; Qi Chen; Xiaonan Xiong; Chuang Zhang; Jingjing Qian; Jie Shi; Qiong An; Ming Zhang

来源：Chinese Chemical Letters, 2018, 29(12): 1893-1896.

• Gold(I) complex
• Multicomponent reaction
• Nitrogen heterocycles
• Room temperature
• Pyrroles

A gold(Ⅰ)-catalyzed three-component reaction of β-nitrostyrenes with 1,3-dicarbonyl compounds and primary amines to form polysubstituted pyrroles has been developed at room temperature in ethanol.The key advantages of the three-component reaction are the mild reaction conditions and environmentally safer solvent.

• 单位
  南京医科大学