科研之友
微信
新浪微博
Facebook
分享链接
摘要
Peyronie＊s Disease (PD) remains a challenging and clinically significant morbid condition. Since its first description by Franˋois Gigot de la Peyronie, much of the treatment for PD remains nonstandardized. PD is characterized by the formation of fibrous plaques at the level of the tunica albuginea. Clinical manifestations include morphologic changes, such as curvatures and hourglass deformities. Here, we review the common surgical techniques for the management of patients with PD. 1. Introduction Before the times of Franˋois Gigot de la Peyronie, men have been plagued with the disfiguring and painful disease eventually known as Peyronie＊s disease (PD). Curvature develops from the rigid inelastic tunical scar, secondary to macro-/microtrauma in individuals either predisposed genetically or with an underlying disease process of the network of elastic fibers and collagen bundles. This condition causes severe psychological, mental, and physical stress. The pain, erectile dysfunction, and curvature/defect caused by the plaque can prevent proper coitus, potentially resulting in embarrassment and frustration, which may lead to inability to maintain sexual relations. Despite the attempts to uncover the pathophysiology behind PD, it still remains an enigma. It has an estimated prevalence of 3每9% although its incidence has increased in recent years [1]. This is partly because men are less embarrassed and more willing to come forth for treatment, rather than silently suffer the pain and difficulties associated with PD. PD can be characterized by two separate phases. The active (acute) phase is characterized by a painful and evolving plaque, inflammation, and progression of the curvature. This usually lasts 6 to 18 months. Approximately 10% of patients will have improvement in their disease. The majority of patients will experience maintenance or worsening of the defect. Once the disease has been stable for approximately 6 months, this is considered the stable (chronic) phase, at which time surgical treatment is appropriate [2, 3]. In the 18th century, de la Peyronie attempted to treat this ailment by recommending mercurial rubs and bathing in the waters of the River Berges [1, 4]. A multitude of minimally invasive therapies currently exist, including but not limited to, vitamin E (Tocopherol), aminobenzoate potassium (Potaba), colchicine, tamoxifen, intralesional injection therapy with verapamil, interferon, and steroids. Medical treatments have been plagued with flawed results, poorly designed studies, and conflicting data [4]. Surgery remains the mainstay in
