异氟醚浓度相关的对伤害性刺激的双向反应及作用机制

作者：武晓文; 于布为

来源：国际麻醉学与复苏杂志, 2006, (04): 252-255.

DOI：10.3760/cma.j.issn.1673-4378.2006.04.018

• isoflurane
• hyperalgesia
• antinociception
• mechanisms

Isoflurane has the dual effects on nociceptive stimulation. It produces hyperalgeia at low partial pressure (0.1 MAC), while displays an antinociceptive effect at higher concentrations (0.4 MAC~0.6 MAC). The different actions of isoflurane on Aδ and C fibers of the spinal cord, and the neuronal nicotinic acetylchlorine receptors (nAChRs), adrenoceptors (including α1 and α2 receptors), excitatory neuronal synaptic transmission ( NMDAergic and AMPAergic), and inhibitory neuronal synaptic transmission ( GABAergic and glycinergic), substance P, and c-fos gene in the central never system may contribute to the mechanisms of isoflurane’s dual effects.

• 单位
  上海交通大学医学院附属瑞金医院